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    1. Computational and Systems Biology
    2. Neuroscience

    Temporal pattern and synergy influence activity of ERK signaling pathways during L-LTP induction

    Nadiatou T Miningou Zobon, Joanna Jędrzejewska-Szmek, Kim T Blackwell
    ERK activation during induction of long-term synaptic plasticity is enhanced by synergistic interactions among signaling pathways mediated by the synaptically located GTPase-activating protein, and each pathway contributes to different ERK temporal dynamics.
    1. Cancer Biology

    The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression

    Nehal Gupta, Hanbing Song ... Ross A Okimoto
    Mutual suppression of ETV1 by Capicua (CIC) and ETS2 repressor factor (ERF) limits prostate cancer progression.
    1. Chromosomes and Gene Expression

    Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

    Dawn Z Eichenfield, Ty Dale Troutman ... Christopher K Glass
    Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.
    1. Developmental Biology
    2. Plant Biology

    Selective egg cell polyspermy bypasses the triploid block

    Yanbo Mao, Alexander Gabel ... Rita Groß-Hardt
    A ménàge à trois introduces extra DNA only to plant embryos, thus skipping endosperm-induced seed hybridization barriers.
    1. Cancer Biology
    2. Cell Biology

    Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

    Natalia Vydra, Patryk Janus ... Wieslawa Widlak
    Heat shock factor 1 is involved in estrogen-induced chromatin remodeling in estrogen receptor-positive breast cancer cells.
    1. Cell Biology

    Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1α

    Silvia Gómez-Puerta, Roberto Ferrero ... Franka Voigt
    Development of a live single-molecule imaging approach to visualize XBP1 mRNAs, which are recruited for translation on the ER and efficiently spliced in the absence of large IRE1α foci.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber, Thomas Roder ... Matthias Erb
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Ecology

    Benefits of jasmonate-dependent defenses against vertebrate herbivores in nature

    Ricardo AR Machado, Mark McClure ... Matthias Erb
    Uncovering an link between plant defense signaling and vertebrate feeding behavior suggests that large browsers may exert strong selection pressure on jasmonate-dependent secondary metabolites.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter, Roberta Schulte ... Martin Hetzer
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad, Clément Chapat ... Nahum Sonenberg
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.