Browse the search results

Compounds that activate integrated stress response kinases inhibit mitochondrial fragmentation induced by chemical or genetic insults, indicating that targeting this pathway offers opportunities to mitigate mitochondrial fragmentation in diverse diseases.

Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.

A ligand independent mechanical sensitive mTORC2-PKC pathway activates Notch in the endocardium of the valve forming area.

Oversized mammalian cells reduce their growth efficiency by activating global protein degradation, which functions in parallel with the cell size checkpoints, to promote cell size homeostasis.