302 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen et al.
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Genetics and Genomics

    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

    Daniel Wells et al.
    ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
    1. Neuroscience

    Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity

    Erin A Clark et al.
    RORβ is a key layer 4 transcription factor orchestrating a critical juncture in barrel development where terminal differentiation and activity inputs are integrated to drive cellular organization in the cortex.
    1. Neuroscience

    An essential role for MEF2C in the cortical response to loss of sleep in mice

    Theresa E Bjorness et al.
    The transcription factor, MEF2C, mediates a change in approximately one half of the expressed frontal cortical transcriptome controlling cellular metabolism and synaptic strength in response to acute loss of sleep.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku et al.
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Developmental Biology

    A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development

    Kerstin Hasenpusch-Theil et al.
    Primary-cilia-mediated processing of the Gli3 transcription factor enables the formation of subtypes of projection neurons in appropriate numbers during the development of the cerebral cortex.
    1. Medicine
    2. Neuroscience

    What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

    Dan Valsky et al.
    Aberrant striatal signaling does not induce drastic changes in the spontaneous discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia.
    1. Developmental Biology

    DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

    Maria M Mikedis et al.
    DAZL promotes male fertility by enhancing the protein expression of thousands of genes to facilitate expansion and differentiation of transit-amplifying spermatogonia in the testes.
    1. Developmental Biology
    2. Neuroscience

    Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6

    Nathalie Coré et al.
    Vax1 suppresses dopaminergic neuron phenotype by inhibiting Pax6 expression in the subventricular zone of the lateral ventricle and is necessary to generate Calbindin interneurons for the postnatal olfactory bulb.
    1. Computational and Systems Biology
    2. Neuroscience

    A sensorimotor model shows why a spectral jamming avoidance response does not help bats deal with jamming

    Omer Mazar, Yossi Yovel
    An elaborated bat-predator model shows that even in high bat-densities, bats can successfully catch flying insects and that changing their signals’ frequency is not necessary for dealing with sensory interference.

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