2,130 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments

    Scott D Hansen, R Dyche Mullins
    Lamellipodin, an important regulator of cytoskeletal and assembly cell migration, enhances the activity of Ena/VASP family actin polymerases by clustering them on leading-edge membranes and tethering them to actin filaments.
    1. Cell Biology

    Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion

    Julia Damiano-Guercio et al.
    Ena/VASP proteins act as positive regulators of cell motility and are required for the formation of microspikes, as opposed to filopodia that can arise from distinct molecular mechanisms.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

    Grégory Verdon et al.
    Crystal structures of an archaeal homologue of mammalian glutamate transporters in apo and ion-only bound outward- and inward-facing states reveal ion-coupled conformational changes supporting mechanisms of coupling, gating, and transport.
    1. Physics of Living Systems
    2. Cell Biology

    Side-binding proteins modulate actin filament dynamics

    Alvaro H Crevenna et al.
    The kinetics of actin polymerization are strongly influenced by the binding of proteins to the lateral filament surface.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera et al.
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Cell Biology
    2. Developmental Biology

    Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes

    David C Zebrowski et al.
    Mammal hearts are unable to replace lost cardiomyocytes, which may be due to the loss of centrosome integrity in these cells after birth.
    1. Developmental Biology
    2. Genetics and Genomics

    An atlas of cell types in the mouse epididymis and vas deferens

    Vera D Rinaldi et al.
    A systematic survey of the epididymis identifies the cell types involved in post-testicular maturation of sperm.
    1. Cell Biology

    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

    Nathaniel L Hepowit et al.
    Ser57 phosphorylation of ubiquitin protects the cell during proteotoxic stress.
    1. Genetics and Genomics

    A confinable home-and-rescue gene drive for population modification

    Nikolay P Kandul et al.
    Generation of a home-and-rescue gene drive targeting an essential gene reveals confinable population modification.
    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.

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