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Age-dependent changes in DNA methylation are tightly coupled to the metabolic state, and is partly under genetic regulation, and longer lifespan is associated with lower epigenetic entropy at CpGs that increase in methylation with age.

Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.

The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.

The dynamic current generated Na⁺/K⁺ pump interacts with the h-current to control the bursting activity of oscillator heart interneurons.

While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.

Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.