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    1. Cell Biology

    Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Gongzheng Hu
    The combination therapy of colistin, artesunate, and EDTA could serve as a promising approach to combat colistin-resistant Salmonella infections by disrupting bacterial membranes, collapsing proton motive force, and increasing reactive oxygen species levels.
    1. Ecology
    2. Microbiology and Infectious Disease

    Global landscape of phenazine biosynthesis and biodegradation reveals species-specific colonization patterns in agricultural soils and crop microbiomes

    Daniel Dar, Linda S Thomashow ... Dianne K Newman
    Computational approach quantifies the abundance of phenazine-antibiotic producing and biodegrading bacteria in diverse soil and plant-associated habitats.
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

    Ioannis Galdadas, Shen Qu ... Shozeb Haider
    A combination of equilibrium and nonequilibrium molecular dynamics simulations is an effective tool to study allosteric communications in ultrafast enzymes that show little or no conformational changes.
    1. Microbiology and Infectious Disease

    Tools and methods for high-throughput single-cell imaging with the mother machine

    Ryan Thiermann, Michael Sandler ... Suckjoon Jun
    A user-friendly pipeline for analysis of time-lapse imaging data from the microfluidic mother machine.
    1. Ecology
    2. Microbiology and Infectious Disease

    Relationships between community composition, productivity and invasion resistance in semi-natural bacterial microcosms

    Matt Lloyd Jones, Damian William Rivett ... Thomas Bell
    Resident members of natural bacterial communities limit the growth of non-resident bacteria primarily by increasing overall community growth.
    1. Microbiology and Infectious Disease

    Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases

    Julia Takuno Hespanhol, Daniel Enrique Sanchez-Limache ... Ethel Bayer-Santos
    Salmonella antibacterial effectors act on Y-shaped DNA substrates resembling replication forks or transcription bubbles and lead to DNA double-strand breaks.
    1. Immunology and Inflammation

    Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Genetics and Genomics

    Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage

    Carla Gonçalves, Jennifer H Wisecaver ... Paula Gonçalves
    Comparative genomics coupled with genetic and biochemical studies show that central carbon metabolism in fungi can be remodeled by genes originating from bacteria.