10 results found
    1. Developmental Biology

    Notochord: Patterning the spine

    Matthew P Harris, Gloria Arratia
    Experiments have shed new light on the development of the spine in zebrafish.
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    1. Developmental Biology

    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

    Laura Lleras Forero et al.
    In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin et al.
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Developmental Biology

    The invariant cleavage pattern displayed by ascidian embryos depends on spindle positioning along the cell's longest axis in the apical plane and relies on asynchronous cell divisions

    Rémi Dumollard et al.
    Cell cycle asynchrony regulates apical cell shape to drive cell division orientation in the apical plane.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Connexin-43-dependent ATP release mediates macrophage activation during sepsis

    Michel Dosch et al.
    Autocrine activation of macrophages is modulated by Connexin-43-mediated ATP release in response to TLR-4 and -2 agonists in a P2Y1-dependent manner, ultimately determining sepsis survival.
    1. Developmental Biology

    Taste bud formation depends on taste nerves

    Di Fan et al.
    The sensory nerves that carry sensations from the taste buds to the brain induce the formation of the taste buds in the embryo.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic and epigenetic variation in the lineage specification of regulatory T cells

    Aaron Arvey et al.
    There is limited epigenetic conservation of lineage-specific DNA elements in Treg cells, and genetic variation in Treg cell specific enhancers is associated with autoimmune disease.
    1. Cell Biology

    COPI selectively drives maturation of the early Golgi

    Effrosyni Papanikou et al.
    Inactivation of the COPI vesicle coat in yeast reveals that COPI recycles early but not late Golgi proteins.
    1. Stem Cells and Regenerative Medicine

    Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

    Juan Carlos Lopez-Baez et al.
    Wound-specific notochord sheath cell subpopulations associate with notochord repair and adult vertebrae formation.
    1. Cell Biology

    Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits

    Mirko Messa et al.
    Epsin has a key role in the coupling of actin to endocytic clathrin coated pits that is required for their maturation and helps capture SNAREs at endocytic clathrin coated pits.

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