521 results found
    1. Structural Biology and Molecular Biophysics

    Specific Eph receptor-cytoplasmic effector signaling mediated by SAM–SAM domain interactions

    Yue Wang et al.
    Comparative structural studies reveal how the cytoplasmic tails of Eph receptors can differentiate different downstream target proteins via highly specific SAM–SAM domain interactions.
    1. Developmental Biology

    Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness

    Jordi Cayuso et al.
    Boundary cell identity and sharpening of borders are coupled in hindbrain development since both are regulated by mechanical tension.
    1. Structural Biology and Molecular Biophysics

    A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration

    Daiane S Alves et al.
    The transmembrane domain of the EphA2 receptor has been transformed into a novel amphitropic peptide that binds to the EphA2 receptor and inhibits cell migration.
    1. Neuroscience

    Presenilin/γ-secretase-dependent EphA3 processing mediates axon elongation through non-muscle myosin IIA

    Míriam Javier-Torrent et al.
    EphA signaling plays dual opposite roles on axon dynamics in neurons, so it inhibits and promotes axon growth through ligand binding and receptor processing, respectively.
  1. Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos

    Oliver A Krupke et al.
    Eph receptor signaling commonly excludes migrating embryonic cells from regions of high ligand density; however, in sea urchin embryos pigmented immunocytes are attracted to regions expressing high levels of Ephrin.
    1. Evolutionary Biology
    2. Neuroscience

    Pheromones: The taste of togetherness

    Jonathan Trevorrow Clark, Anandasankar Ray
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

    Ching-Ju Tsai et al.
    The structure of a light-sensitive G protein-coupled receptor in complex with a Gi-protein heterotrimer provides a structural foundation for the role of the receptor C-terminal tail in scaffolding and signaling.
    1. Neuroscience

    Olfactory connectivity mediates sleep-dependent food choices in humans

    Surabhi Bhutani et al.
    Sleep deprivation enhances energy-dense food choices and encoding of olfactory information in the human brain.
    1. Neuroscience

    Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

    Jordan N Norwood et al.
    Chemical ablation of olfactory sensory neurons blocks cerebrospinal fluid outflow into the nasal epithelium, leading to alterations of cerebrospinal fluid dynamics.
    1. Human Biology and Medicine
    2. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.

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