Single-cell analysis of injured mouse sciatic nerves reveals rapid reprogramming of macrophages toward a glycolytic, proinflammatory phenotype during the early repair process.
Graded Wnt and JAK-STAT signals regulate the division rate, AP location and differentiation of Drosophila ovarian follicle stem cells to define a domain of stem cells maintained by population asymmetry.
A high-throughput method to profile tyrosine kinases and phosphotyrosine recognition domains reveals new rules for sequence specificity and maps the effects of mutations on the recognition of tyrosine phosphorylation sites.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
Cathryn R Cadwell, Federico Scala ... Andreas Savas Tolias
Excitatory cortical neurons with a shared developmental lineage are transcriptomically diverse and preferentially connect to each other vertically, across cortical layers, but not laterally within the same layer.
The coactivity of cortical neurons in associative learning recruits them as associative memory cells based on their synapse interconnections by neuroligin-3-mediated synapse formation, which endorses the first order and the second order of associative memory.