339 results found
    1. Neuroscience

    Memory recall involves a transient break in excitatory-inhibitory balance

    Renée S Koolschijn et al.
    Hippocampal activity during memory recall predicts a transient increase in the ratio between neocortical glutamate and GABA, thereby allowing otherwise dormant memories to be released.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Developmental Biology
    2. Neuroscience

    Activity-dependent modulation of synapse-regulating genes in astrocytes

    Isabella Farhy-Tselnicker et al.
    RNA sequencing and genetic mouse models reveal that transcriptional changes to astrocytes in the developing cortex are not intrinsic but influenced by their environment and determine that expression of astrocyte synapse-regulating genes and neuronal synaptogenesis is modulated by ongoing astrocyte-neuron communication.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Precise optical control of gene expression in C elegans using improved genetic code expansion and Cre recombinase

    Lloyd Davis et al.
    A method combining optimised genetic code expansion and optogenetics allows dissection of neural circuits with single-cell precision in freely moving animals.
    1. Neuroscience

    Reexamination of N-terminal domains of syntaxin-1 in vesicle fusion from central murine synapses

    Gülçin Vardar et al.
    A mutant rescue approach in STX1-null autaptic neurons provides definitive answers and opens up new questions into a controversial matter of syntaxin-1's binding to Munc18-1 through its N-peptide and its function in neurotransmission.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
    1. Neuroscience

    Cortical excitability signatures for the degree of sleepiness in human

    Chin-Hsuan Chia et al.
    Patterns of cortical excitability changes reflect the degree of sleepiness in humans.
    1. Cancer Biology

    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Carolina Marques et al.
    Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.
    1. Genetics and Genomics

    Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity

    Stephen M Blazie et al.
    The eIF3 translation initiation complex exerts specific regulation on neuronal protein levels by targeting mRNAs with GC-rich 5' UTR.
    1. Neuroscience

    Causal neural mechanisms of context-based object recognition

    Miles Wischnewski, Marius V Peelen
    Context-based object recognition causally relies on both scene- and object-selective cortex, with scene-selective cortex generating expectations (at 160-200 ms after onset) that disambiguate object representations in object-selective cortex (at 260-300 ms after onset).

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