Amy Richardson, Victoria Ciampani ... Ian D Forsythe
The Kv3.3 potassium channel subunit is necessary and sufficient to permit presynaptic location and accelerated repolarisation of the presynaptic action potential, thereby conserving resources and enhancing accuracy of timing information on transmission at the calyx of Held excitatory synapse.
Retinal physiology and anatomy and visual behavior reveal how sensory circuits in the retina can shape an organism’s eye movements over a range of ethologically relevant stimulus conditions.
The THAP-domain protein Bip1, along with other proteins Nup98 and RpS8, controls the expression of the protein Pvr, a critical non-cell-autonomous regulator of Drosophila blood progenitor maintenance.
Benjamin H Meyer, Panagiotis S Adam ... Helge C Dorfmueller
The crenarchaeon Sulfolobus synthesizes the N-glycan core in the identical way as all Eukaryotes, which strengthens the hypothesis that the eukaryotic N-glycosylation is acquired from an ancient archaeon during eukaryogenesis.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio
Transient recruitment of electrical synapses mediates precisely timed excitation and inhibition to enhance synchronized control of cerebellar cortical output.
Christian Keine, Mohammed Al-Yaari ... Samuel M Young Jr
A combination of genetic, electrophysiological, and modeling approaches reveals that presynaptic Rac1 is a key molecule that controls synaptic strength and plasticity by regulating the synaptic vesicle cycle steps controlling the number of fusion competent synaptic vesicles.
Genetic and electrophysiological experiments define how homeostatic signaling stabilizes both the gain and short-term dynamic properties of neurotransmitter release, ensuring that synaptic information transfer remains robust to external perturbation.
MCTP is a novel presynaptic calcium sensor, resident within the endoplasmic reticulum, that is required for normal baseline neurotransmission, short-term synaptic plasticity and presynaptic homeostatic plasticity.
The compactness of synaptic release sites coupled with their four-fold number in humans compared to rats provides unprecedented scaleability in operation of human synapses.
Young neurons of the adult hippocampus are synaptically activated by a small group of non-overlapping afferent excitatory fibers, due to high synaptic gain and sparse connectivity, important for sparse and orthogonal coding during hippocampal information processing.
