Understudied atypical MAPK, ERK3 controls epithelial secretome and chemotaxis.

Cell-based high-throughput screening identifies IBT21 as a chemical chaperone, that inhibits ER protein aggregation and prevents the cell death caused by a proteotoxin, the aggregation-prone prion protein.

Sphingolipids govern the compartmentalization of yeast cells through the assembly of lateral diffusion barriers in ER membranes.

ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.

The transcription factor ERG recruits the PRMT5 enzyme to methylate the androgen receptor, presenting a post-translational regulatory mechanism that could be therapeutically exploited to control cell proliferation.

Combinatorial signaling leads to transcription factor co-localization at Rev-erb sensitive enhancers, enabling a diversified cellular response to complex stimuli.

Endoplasmic reticulum (ER) inheritance regulation during ER stress controls the transmission of misfolded ER proteins from mother to daughter cell in budding yeast.

One minute biotinylation with APEX2 peroxidase in living cells identifies established and new components of mitochondrial and ER membranes; dataset intersection and overexpression screen identifies SYNJ2BP overexpression as inducing mitochondria-rough ER contacts.

Genetic and biochemical analyses reveal that PERK is important for the survival of activated satellite stem cells during regeneration of injured skeletal muscle.

Two cell-penetrating peptides that inhibit Ras-ERK signalling and a potent clinically relevant MEK inhibitor block cocaine conditioned place preference and accelerate extinction of cocaine self-administration upon a single administration in mice.