3,794 results found
    1. Genetics and Genomics
    2. Cancer Biology

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy K Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    Igor Kondrychyn, Liqun He ... Li-Kun Phng
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Evolutionary Biology

    Large inversions in Lake Malawi cichlids are associated with habitat preference, lineage, and sex determination

    Nikesh M Kumar, Taylor L Cooper ... Patrick T McGrath
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Neuroscience

    Predicting individual traits from models of brain dynamics accurately and reliably using the Fisher kernel

    Christine Ahrends, Mark W Woolrich, Diego Vidaurre
    The HMM-Fisher kernel approach leverages individual signatures of brain dynamics for prediction, which can be used, for example, to search for brain dynamics-informed biomarkers of neuropsychiatric disease or predict treatment response.
    1. Developmental Biology
    2. Genetics and Genomics

    Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

    Mehul Vora, Jonathan Dietz ... Cathy Savage-Dunn
    Smad and Schnurri transcription factors engage in context-dependent interactions as well as independent genomic activities, leading to regulation of collagen secretion to mediate body size regulation in C. elegans.
    1. Immunology and Inflammation

    Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

    Weigao Zhang, Hu Liu ... Dan Weng
    Hepatocyte RIPK1 plays an important role in liver physiology, preventing liver injury and inflammation during metabolic stresses like acute fasting.
    1. Neuroscience

    Glia control experience-dependent plasticity in an olfactory critical period

    Hans C Leier, Alexander J Foden ... Heather T Broihier
    A Drosophila olfactory circuit exhibits experience-dependent glial pruning during a well-defined critical period, with long-term consequences for odor processing.
    1. Cell Biology

    PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response

    Ling Cheng, Ian Meliala ... Mikael Björklund
    A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation mechanisms.
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing

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