1,653 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

    Jack F Cazet et al.
    Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

    Yihu Xie et al.
    Cryo-EM and chemical cross-linking studies yield an atomic resolution structure of a conserved remodeling machinery in messenger ribonucleoprotein maturation/nuclear export and insights into its coordinated function with a serine–arginine protein.
    1. Biochemistry and Chemical Biology

    Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    Phil Huss et al.
    An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
    1. Ecology

    Relative demographic susceptibility does not explain the extinction chronology of Sahul’s megafauna

    Corey JA Bradshaw et al.
    There is no relationship between the demographic susceptibility to extinction and the estimated extinction chronology among Sahul’s megafauna, suggesting that human choices, a species’ ecological requirements, and/or random climate variation instead determined the extinction chronology.
    1. Genetics and Genomics

    Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

    Astrid Hoermann et al.
    Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

    Tingting Wang et al.
    The transcription factor (TF)-binding specificities of Pseudomonas aeruginosa allow us to predict virulence-associated TFs and their target genes, which will facilitate to find effective treatment and prevention for its associated diseases.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

    Philipp Kolb et al.
    Molecular mechanisms reveal that human cytomegalovirus has evolved to deploy two individual glycoproteins working in synergy to efficiently evade antibody-mediated immunity mediated by Fc-gamma receptors.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

    Deniz Cizmeci et al.
    Extended somatic hypermutation and clonal evolution associated with antibody neutralization breath in HIV controllers with low plasma viral loads provide promise for HIV vaccine development.
    1. Neuroscience

    Mother brain is wired for social moments

    Ortal Shimon-Raz et al.
    Mother brain shows special sensitivity to social moments of mother-infant synchrony, compared to other caregiving experiences, through enhanced activation across the caregiving network, response to oxytocin administration, and temporal consistency.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integron activity accelerates the evolution of antibiotic resistance

    Célia Souque et al.
    Integrons deploy a variety of adaptive strategies including excision, shuffling, and duplication of cassettes that foster rapid bacterial adaptation and resistance evolution while protecting the genomic integrity of the host.

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