1,749 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes

    Samantha Ebersoll et al.
    African trypanosomes have a trypanothione-based mitochondrial thiol redox metabolism.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks

    Eugenia Lyashenko et al.
    Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni et al.
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Cell Biology
    2. Physics of Living Systems

    Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

    Matthew Akamatsu et al.
    An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.
    1. Developmental Biology
    2. Genetics and Genomics

    An alternatively spliced, non-signaling insulin receptor modulates insulin sensitivity via insulin peptide sequestration in C. elegans

    Bryan A Martinez et al.
    A truncated, non-signaling insulin receptor regulates insulin sensitivity in the nematode C. elegans by sequestering insulin peptides and preventing their interaction with full length receptors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

    Miriam Stoeber et al.
    Chemically distinct opioid ligands promote selective protein recruitment by opioid receptors in intact cells.
    1. Neuroscience

    Paradoxical network excitation by glutamate release from VGluT3+ GABAergic interneurons

    Kenneth A Pelkey et al.
    Glutamate cotransmission from a subset of cortical GABAergic interneurons can promote network hyperexcitability.
    1. Cell Biology

    Control of cell death/survival balance by the MET dependence receptor

    Leslie Duplaquet et al.
    MET acts as a dependence receptor in vivo by promoting hepatocyte apoptosis, a response induced by a caspase generated fragment able to favor calcium exchange between endoplasmic reticulum and mitochondria.
    1. Genetics and Genomics
    2. Neuroscience

    A genetic, genomic, and computational resource for exploring neural circuit function

    Fred P Davis et al.
    Transcriptomes of cells in the Drosophila visual system combined with anatomy and other information reveal new functional insight into the visual circuit.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.

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