512 results found
    1. Structural Biology and Molecular Biophysics

    Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals

    Chimari Jiko et al.
    The transmembrane shape of the F1Fo ATP synthase monomer provides the molecular basis of high curvature at the ridges of mammalian mitochondrial cristae.
    1. Cell Biology

    The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

    Suzanne Angeli et al.
    Loss of the F-ATP synthase c-subunit inhibits a pathological mitochondrial permeability transition pore that is coupled to a maladaptive mitochondrial unfolded protein response while also extending lifespan.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An evidence based hypothesis on the existence of two pathways of mitochondrial crista formation

    Max E Harner et al.
    Lamellar and tubular cristae in mitochondria form by two different molecular pathways that form both involve F1FO-ATP synthase dimers and the MICOS complex, but formation of lamellar cristae also relies on Mgm1/Opa1.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the autoinhibited E. coli ATP synthase in three rotational states

    Meghna Sobti et al.
    A molecular model that provides a framework for interpreting the wealth of functional information obtained on the E. coli F-ATP synthase has been generated using cryo-electron microscopy.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf et al.
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Structural Biology and Molecular Biophysics

    Atomistic simulations indicate the c-subunit ring of the F1Fo ATP synthase is not the mitochondrial permeability transition pore

    Wenchang Zhou et al.
    The notion that the lumen of the ATP synthase membrane rotor is the long-sought megachannel that triggers the onset of the mitochondrial permeability transition is found to be inconsistent with its actual structural and functional properties.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

    Anna Zhou et al.
    Structural analysis of the ATP synthase – in combination with evolutionary covariance analysis – reveals the fold of the a subunit and shows that the enzyme can adopt several different conformations, which support the Brownian ratchet model for generating rotation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Identification of cryptic subunits from an apicomplexan ATP synthase

    Diego Huet et al.
    A phylum-specific ATP synthase subunit is needed for proper mitochondrial function and stability of the complex in Toxoplasma gondii.
    1. Biochemistry and Chemical Biology

    Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

    Ryoji Miyazaki et al.
    Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
    1. Structural Biology and Molecular Biophysics

    Mechanical inhibition of isolated Vo from V/A-ATPase for proton conductance

    Jun-ichi Kishikawa et al.
    Cryo-EM structures of rotary V-ATPase reveal the ON-OFF switching mechanism of H+ translocation in the Vo membrane domain.

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