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    1. Physics of Living Systems

    Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

    Feng-Ching Tsai, Aurelie Bertin ... Patricia Bassereau
    Ezrin, an important actin-membrane linker, can zip adjacent membranes, be enriched to positively-curved membranes when phosphorylated and to negatively-curved membranes through a direct interaction with membrane curvature sensor I-BAR domain proteins.
    1. Neuroscience

    Regional response to light illuminance across the human hypothalamus

    Islay Campbell, Roya Sharifpour ... Gilles Vandewalle
    Distinct local dynamics of different hypothalamus areas were detected in response to changing illuminance and could contribute to light’s impact on cognition.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Controlling SARS-CoV-2 in schools using repetitive testing strategies

    Andrea Torneri, Lander Willem ... Pieter JK Libin
    In primary schools, where vaccination coverage can be low, a repetitive testing strategy reduces SARS-CoV-2 infections while keeping classes and schools open, as such limiting infection transmissions and absenteeism.
    1. Developmental Biology
    2. Neuroscience

    EZ Clear for simple, rapid, and robust mouse whole organ clearing

    Chih-Wei Hsu, Juan Cerda III ... Joshua D Wythe
    With three simple steps in 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while simultaneously preserving signal from synthetic and endogenous fluorescent reporters and is compatible with wholemount immunostaining and cryosectioning followed by histological or immunofluorescent staining.
    1. Structural Biology and Molecular Biophysics

    Functional implications of MIR domains in protein O-mannosylation

    Antonella Chiapparino, Antonija Grbavac ... Irmgard Sinning
    The MIR domain of protein-O-mannosyltransferases participates in glycosylation by binding mannosylated peptides and regulates enzyme processivity.
    1. Neuroscience

    Gamma rhythms and visual information in mouse V1 specifically modulated by somatostatin+ neurons in reticular thalamus

    Mahmood S Hoseini, Bryan Higashikubo ... Jeanne T Paz
    Gamma rhythms and representation of visual information in the primary visual cortex are specifically modulated by somatostatin+ but not parvalbumin+ neurons in reticular thalamic nucleus.
    1. Neuroscience

    scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition

    Chi Zhang, Ming-Wen Hu ... Yun Guan
    Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger, Jarod A Rollins ... Markus Schosserer
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
    1. Cell Biology
    2. Developmental Biology

    The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

    Marianthi Kiparaki, Chaitali Khan ... Nicholas E Baker
    Ribosomal protein mutations, mutations that affect ribosomal RNA synthesis, or function of the mature ribosome, trigger a transcriptional response mediated by Xrp1 expression which reduces cellular translation via eIF2-alpha phosphorylation and renders cells liable to competition with wild-type neighbors.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Updates to the zoonotic niche map of Ebola virus disease in Africa

    David M Pigott, Anoushka I Millear ... Simon I Hay
    Building on previous work (Pigott et al. 2014), estimates of areas of potential transmission of Ebola virus are revised and updated to provide a contemporary map for use by researchers and policymakers.