69 results found
    1. Developmental Biology
    2. Human Biology and Medicine

    Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma

    Benjamin R Thomson et al.
    Genetic deletion of one Ptprb allele leads to increased phosphorylation of the TEK receptor, increasing Schlemm's canal area and protecting retinal ganglion cells in a mouse model of glaucoma.
    1. Developmental Biology

    N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

    Elif Kon et al.
    FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
    1. Cell Biology
    2. Developmental Biology

    BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

    Hyung-Seok Kim et al.
    Endogenous BMP2/7 and BMP4/7 heterodimers form in vivo, and are the predominant functional ligand in many, if not all, tissues of developing mouse embryos.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hemozoin produced by mammals confers heme tolerance

    Rini H Pek et al.
    Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.
    1. Developmental Biology

    An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis

    Melanie Laurin et al.
    An unprecedented large-scale screen in mice for morphogenetic regulators of tissue development provides major new insights into the roles of Rho GTPases in diverse array of skin developmental processes.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis

    Jinsheng Zhu et al.
    Genetic and biochemical analysis of two enzymes reveals that inositol pyrophosphate signaling molecules allow plants to sense and regulate cellular phosphate levels, and to take up more phosphate when needed.
    1. Cell Biology
    2. Neuroscience

    Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

    Veronica Cloud et al.
    An unbiased biochemical screen reveals a direct link between gene regulation and actin cytoskeleton remodeling.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Cell Biology

    Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish

    Veronika Miskolci et al.
    Thermal injury and infected wounds induce distinct inflammatory and remodeling mechanisms that alter the dynamics of wound repair.
    1. Neuroscience

    Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body

    Michael-John Dolan et al.
    The generation and systematic characterisation of driver lines labelling a large number of neurons in the Drosophila innate olfactory processing centre bridges electron microscopy neuronal reconstructions, circuits and behaviour.

Refine your results by:

Type
Research categories