47 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

    Kasper R Andersen et al.
    Components of the nuclear pore complex share structural and functional features with soluble nuclear transport receptors, which suggests that there may be an evolutionary relationship between these two types of protein.
    1. Structural Biology and Molecular Biophysics

    Spatial structure of disordered proteins dictates conductance and selectivity in nuclear pore complex mimics

    Adithya N Ananth et al.
    Biomimetic nanopores reveal that the sequence-dependent spatial distribution of intrinsically disordered proteins plays a crucial role in establishing the selective permeability barrier of the nuclear pore complex.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Simple biophysics underpins collective conformations of the intrinsically disordered proteins of the Nuclear Pore Complex

    Andrei Vovk et al.
    Simple biophysical considerations explain the collective behavior of molecularly diverse complex protein assemblies that regulate transport between the nucleus and the cytoplasm in eukaryotic organisms.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

    Melissa Kane et al.
    Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

    Alan R Lowe et al.
    The Ran GTPase plays a role in defining the physical properties of the nuclear pore complex transport channel by remodeling the binding interactions of importin-β with the nucleoporin Nup153 at the nuclear face of the pore.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci et al.
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The molecular mechanism of nuclear transport revealed by atomic-scale measurements

    Loren E Hough et al.
    NMR spectroscopy has been used to explain a central unresolved issue of nuclear transport, namely how it can be both fast and specific.
    1. Cell Biology

    Conformation of the nuclear pore in living cells is modulated by transport state

    Joan Pulupa et al.
    Polarized fluorescence microscopy of individual nuclear pores in vivo reveals conformational changes in select domains of proteins of the inner ring.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Channel nuclear pore complex subunits are required for transposon silencing in Drosophila

    Marzia Munafò et al.
    By linking export and licensing of a piRNA precursor transcript, channel nuclear pore complex subunits Nup54 and Nup58 are specifically required to silence transposons in the Drosophila ovary.
    1. Cell Biology

    Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

    Irina L Rempel et al.
    In replicative ageing yeast cells, an age-dependent impediment in proper assembly of nuclear pore complexes is associated with altered nuclear transport.

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