894 results found
    1. Developmental Biology and Stem Cells

    Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome

    Tian Yu et al.
    Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.
    1. Cell Biology

    EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

    Itziar Pinilla-Macua et al.
    A small pool of active epidermal growth factor (EGF) receptors, which are capable of ubiquitylation and efficient endocytosis in vivo, is sufficient to support EGF-receptor-dependent tumor growth by signaling primarily through the Ras-MAPK pathway.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    Crk proteins transduce FGF signaling to promote lens fiber cell elongation

    Tamica N Collins et al.
    Crk proteins are critical mediators of FGF signaling to control cell shape changes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran et al.
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.
    1. Developmental Biology and Stem Cells

    FGF mediated MAPK and PI3K/Akt Signals make distinct contributions to pluripotency and the establishment of Neural Crest

    Lauren Geary, Carole LaBonne
    A role for FGF-mediated Map Kinase signaling in the retention of pluripotency underlying genesis of Neural Crest is revealed, along with a striking switch in the signaling cascades activated by FGF signaling as cells commence lineage restriction.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

    Sung-Ho Huh et al.
    Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
    1. Neuroscience

    Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2

    Elizabeth D Kirby et al.
    Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.
    1. Neuroscience

    Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain

    Naoyuki Matsumoto et al.
    FGF signaling is crucial for gyrus formation, proliferation of outer radial glial cells and expansion of upper layers of the cerebral cortex in gyrencephalic mammals.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

    Shogo Sawaguchi et al.
    The transfer of O-GlcNAc by EOGT to specific EGF repeats of NOTCH1 promotes DLL4 binding, Notch signaling, and retinal vascular development.
    1. Cancer Biology
    2. Cell Biology

    TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

    Debjani Pal et al.
    Phenotypic diversity and cell state transition (i.e., acquisition of a CD44+/CD24- cell state or exposure to TGF-beta) can spur intra-tumor genetic heterogeneity and contribute to acquired resistance.

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