902 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

    Anassuya Ramachandran et al.
    SMAD1/5 signaling is essential for the full transforming growth factor β (TGF-β)-induced transcriptional program and physiological responses and is induced via a novel receptor activation mechanism, involving two distinct type I receptors.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

    Yosuke Yoneyama et al.
    IRS-1, a canonical signaling mediator of IGF-I receptor, serves as an endocytic regulator of IGF-I receptor to facilitate the sustained IGF signaling.
    1. Cell Biology

    Generation of endogenous pH-sensitive EGF receptor and its application in high-throughput screening for proteins involved in clathrin-mediated endocytosis

    Mads Breum Larsen et al.
    CRISPR/Cas9 gene-editing was used to generate a novel endogenous pH-sensitive EGF receptor chimera with the unique utility to study receptor endocytosis in a single-cell and high-throughput experimental formats.
    1. Cell Biology

    EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo

    Itziar Pinilla-Macua et al.
    A small pool of active epidermal growth factor (EGF) receptors, which are capable of ubiquitylation and efficient endocytosis in vivo, is sufficient to support EGF-receptor-dependent tumor growth by signaling primarily through the Ras-MAPK pathway.
    1. Structural Biology and Molecular Biophysics

    How IGF-1 activates its receptor

    Jennifer M Kavran et al.
    Ligand binding to the ectodomain of the insulin-like growth factor receptor destabilises an autoinhibitory inter-subunit interaction, which allows the transmembrane domains to associate and the intracellular regions to autophosphorylate.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

    Huaibin Chen et al.
    A four-switch long-range allosteric network controls FGF receptor kinase conformational dynamics as well as activity and is applicable to other receptor tyrosine kinases.
    1. Developmental Biology
    2. Neuroscience

    Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

    Sung-Ho Huh et al.
    Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
    1. Cell Biology
    2. Developmental Biology

    The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells

    Andrea Haag et al.
    The co-chaperone CHORDC1 is specifically required for epidermal growth factor receptor trafficking and signaling in Caenorhabditis elegans and in human cells.
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco et al.
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Developmental Biology

    Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor

    Leia C Shuhaibar et al.
    Fibroblast growth factor induces dephosphorylation and inactivation of the NPR2 guanylyl cyclase, thus decreasing cyclic GMP production in growth plate chondrocytes and contributing to FGF-dependent decreases in bone growth.

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