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Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling
Sung-Ho Huh et al.
Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
Xiang Zhou et al.
The nerve growth factor receptor (NGFR) protein regulates p53 via two negative feedback mechanisms, which are hijacked by cancer cells.
Computational and Systems Biology
Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways
Harish N Vasudevan et al.
PDGF and FGF signal via distinct intracellular pathways to confer different cellular outcomes during craniofacial development.
Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome
Tian Yu et al.
Mutations in CHD7, which cause CHARGE syndrome, cause a reduction in FGF8 signalling and subsequent abnormalities in the cerebellar vermis in both mice and humans.
Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient
Lijuan Du et al.
FGF morphogen gradient self-generates a recipient tissue-specific contour by feedback-regulating its cytoneme-mediated dispersion.
Stem Cells and Regenerative Medicine
EGFR signaling promotes self-renewal through the establishment of cell polarity in
follicle stem cells
Angela Castanieto et al.
The specification of cell polarity is essential for self-renewal and the segregation of stem-cell and daughter-cell fates in an epithelial stem cell lineage.
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
Elif Kon et al.
FGFRs regulate multipolar cortical neuron orientation and the morphological change into bipolar cells in vivo under the control of N-Cadherin and the extracellular matrix protein Reelin.
Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
Elizabeth D Kirby et al.
Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.
UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
Stéphanie Torrino et al.
UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity
Richard H Row et al.
Interplay between FGF-induced bHLH transcription factors and BMP-induced bHLH inhibitory id genes govern mesodermal cell fate choice along the mediolateral axis in both zebrafish and mouse.
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