200 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

    Suhong Sun et al.
    Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.
    1. Developmental Biology

    Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling

    Ryo Hatori et al.
    Delivery of Hedgehog, Decapentaplegic and Wingless to target cells in the Drosophila wing imaginal disc is regulated in both amount and destination, and is not dependent on constitutive release or uptake from a common pool.
    1. Developmental Biology

    Single-cell RNA analysis identifies pre-migratory neural crest cells expressing markers of differentiated derivatives

    Ezra Lencer et al.
    Pre-migratory and early migratory neural crest cells in zebrafish are transcriptionally diverse, with some cells expressing genes associated with differentiated derivatives while still in the neural tube.
    1. Stem Cells and Regenerative Medicine

    Murine muscle stem cell response to perturbations of the neuromuscular junction are attenuated with aging

    Jacqueline A Larouche et al.
    Muscle stem cells locally respond to perturbations of motor neurons and the neuromuscular junction.
    1. Cancer Biology

    Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

    Yusuke Inoue et al.
    Lineage transformation in lung cancer is dictated by ERK activity and requires permissive chromatin alterations in the context of targeted therapy resistance.
    1. Neuroscience

    5'-UTR SNP of FGF13 causes translational defect and intellectual disability

    Xingyu Pan et al.
    A 5'-UTR SNP of FGF13 impairs PTBP2 interacting with FGF13 mRNA, leading to reduced FGF13 translation and deficits in brain development and cognitive functions.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

    Tisha E Bohr et al.
    Loss of a single organ, the planarian pharynx, triggers immediate proliferation and expansion of stem cells required to replace it.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

    Máté Nászai et al.
    Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
    1. Cell Biology
    2. Medicine

    Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ

    Yang Zhang et al.
    Identifying xanthohumol and its derivatives as PPARγ anatagonists provides new insight into how natural compounds beneficially treat obesity and metabolic syndrome, and provide new compounds for therapeutic development.
    1. Developmental Biology
    2. Genetics and Genomics

    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris

    Brent A Wilkerson et al.
    The elucidation of the cellular composition of the crista and the genes expressed in each cell type is a critical step toward understanding inner ear development, function, and vestibulopathies.

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