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Page 2 of 155
    1. Developmental Biology

    FGF mediated MAPK and PI3K/Akt Signals make distinct contributions to pluripotency and the establishment of Neural Crest

    Lauren Geary, Carole LaBonne
    A role for FGF-mediated Map Kinase signaling in the retention of pluripotency underlying genesis of Neural Crest is revealed, along with a striking switch in the signaling cascades activated by FGF signaling as cells commence lineage restriction.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei, Amir Al Oustah ... Myriam Roussigné
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush, Daniel C Diaz ... Tatjana Piotrowski
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Microbiology and Infectious Disease

    Lipid hijacking: A unifying theme in vector-borne diseases

    Anya J O'Neal, L Rainer Butler ... Joao HF Pedra
    A conceptual and unifying framework with a critical appraisal of lipid hijacking by microbes cycling between an arthropod vector and a mammalian host is explored.
    1. Computational and Systems Biology
    2. Developmental Biology

    Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways

    Harish N Vasudevan, Pierre Mazot ... Philippe Soriano
    PDGF and FGF signal via distinct intracellular pathways to confer different cellular outcomes during craniofacial development.
    1. Structural Biology and Molecular Biophysics

    Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels

    Jacqueline Niu, Ivy E Dick ... Manu Ben-Johny
    Two structurally-unrelated regulatory proteins utilize parallel molecular mechanisms to selectively tune calcium and calmodulin feedback of calcium and sodium ion channels and reveals a novel strategy to engineer synthetic channel modulators.
    1. Developmental Biology

    An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

    Florian Razy-Krajka, Basile Gravez ... Lionel Christiaen
    A gene network for heart versus head muscle specification has been identified in the tunicate Ciona.
    1. Developmental Biology

    Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2

    Xiaobo Wang, Mary Ellenbecker ... Ekaterina Voronina
    Complementary effects of FBF-1 and FBF-2 on germline stem cell dynamics result from their distinct cooperation with mRNA deadenylase resulting in the opposite effects on the shared target mRNAs.
    1. Developmental Biology

    The Warburg Effect and lactate signaling augment Fgf-MAPK to promote sensory-neural development in the otic vesicle

    Husniye Kantarci, Yunzi Gou, Bruce B Riley
    Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.