777 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

    Daniel Andergassen et al.
    The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.
    1. Chromosomes and Gene Expression

    Nonsense mRNA suppression via nonstop decay

    Joshua A Arribere, Andrew Z Fire
    Nonstop mRNA decay degrades mRNAs with a premature stop codon after such mRNAs are targeted by the nonsense-mediated decay machinery.
    1. Neuroscience

    Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity

    Isabelle Straub et al.
    Electrophysiological and computational approaches show that superficial and deep cerebellar granule cells preferentially fire during low- and high-frequency inputs, respectively, enabling a Fourier-like transformation in the granule cell layer.
    1. Neuroscience

    Orbitofrontal neurons acquire responses to ‘valueless’ Pavlovian cues during unblocking

    Michael A McDannald et al.
    Orbitofrontal cortex neurons fire in response to cues with no value independent of what can be inferred through features of the predicted outcome.
    1. Neuroscience

    Activities of visual cortical and hippocampal neurons co-fluctuate in freely moving rats during spatial behavior

    Daniel Christopher Haggerty, Daoyun Ji
    As rats learn to traverse back and forth on a track, visual cortical neurons fire at specific locations and functionally interact with those hippocampal place cells representing the same locations.
    1. Neuroscience

    Hierarchical organization of context in the hippocampal episodic code

    Susumu Takahashi
    Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.
    1. Neuroscience

    Human Intelligence: What single neurons can tell us

    Elaine N Miller, Chet C Sherwood
    IQ scores are correlated with the morphology and activity of certain neurons in the human temporal cortex.
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    1. Neuroscience

    Amyotrophic Lateral Sclerosis: Marking the differences in motoneurons

    Simon A Sharples, Patrick J Whelan
    A subgroup of the neurons that control muscles becomes less excitable shortly before the symptoms of ALS develop.
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