2,838 results found
    1. Structural Biology and Molecular Biophysics

    Structure of the CLC-1 chloride channel from Homo sapiens

    Eunyong Park, Roderick MacKinnon
    A cryo-electron microscopy study of the human CLC-1 chloride ion channel reveals the structural basis of why some CLC proteins function as passive chloride channels whereas others function as an active proton-chloride antiporters.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

    Marina Schrecker et al.
    Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.
    1. Cancer Biology
    2. Genetics and Genomics

    Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells

    Iris E Glykofridis et al.
    Knocking out Folliculin (FLCN) in human renal epithelial cells activates STAT1/2-mediated gene expression, independent of interferon, uncovering a tissue-specific process potentially relevant in the cancer syndrome Birt-Hogg-Dubé (BHD).
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan et al.
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Structural Biology and Molecular Biophysics

    Revealing an outward-facing open conformational state in a CLC Cl/H+ exchange transporter

    Chandra M Khantwal et al.
    The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

    Lilia Leisle et al.
    Combined simulations and electrophysiological experiments show that the CLC channels and exchangers form physically distinct and evolutionarily conserved pathways through which Cl- and H+ ions move when crossing biological membranes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

    Benjamin C McIlwain et al.
    In the extremely selective fluoride channels from the bacterial Fluc family, fluoride ions access the pore via two points, an electropositive vestibule and a triad of conserved residues involved in anion recognition.
    1. Genetics and Genomics
    2. Neuroscience

    Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans

    Chanhyun Park et al.
    A ClC chloride channel protein allows neurons to interpret both temporal resolution and intensity of sensory input, which thereby contributes to an experience-dependent navigation behavior.
    1. Genetics and Genomics

    Spontaneous mutations and the origin and maintenance of quantitative genetic variation

    Wen Huang et al.
    Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.
    1. Cell Biology
    2. Neuroscience

    Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration

    Andrew T Moehlman et al.
    Tuning of BiP activity by Fic-mediated AMPylation is required for Drosophila photoreceptor plasticity and attenuation of the unfolded protein response.

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