1,632 results found
    1. Structural Biology and Molecular Biophysics

    The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

    Susanne Rinné et al.
    A combined systematic alanine scanning and molecular modelling approach reveals the molecular basis for an allosteric inhibition mechanism of K+-flux gating in K2P channels.
    1. Evolutionary Biology

    Fine-tuning citrate synthase flux potentiates and refines metabolic innovation in the Lenski evolution experiment

    Erik M Quandt et al.
    A long-term evolution experiment with Escherichia coli shows that the appearance and optimization of a new trait can require both co-opting existing cellular pathways for new roles and reversing a history of previous adaptation.
    1. Computational and Systems Biology

    Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points

    Uri Barenholz et al.
    The stability of metabolic autocatalytic cycles that are widespread in central metabolism limits the affinities of enzymes at flux branch points and explains excess expression of these enzymes.
    1. Cell Biology
    2. Computational and Systems Biology

    Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins

    Alex X Lu et al.
    100,000s of images from different growth conditions and genetic backgrounds can be integrated into proteome-scale analysis.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

    Bridgette M Cumming et al.
    Quantifiable bioenergetic parameters, determined from extracellular flux analyses, are distinct between macrophages infected with Mycobacteriumtuberculosis or vaccine strain M. bovis BCG, enabling assessment of future vaccine and drug efficacy.
    1. Cell Biology
    2. Human Biology and Medicine

    Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

    Peter Tsvetkov et al.
    Reducing the expression of 19S subunits shifts the ratio of 20S/26S proteasome complexes and provides a powerful survival advantage in the face of lethal proteasome inhibition.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts

    Anika Küken et al.
    Mathematical models reveal that under the physiologically different conditions ambient and high CO2, two algal microcompartments are metabolically connected by facilitated transport.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

    Alexander A Shestov et al.
    A new computational model of the Warburg Effect reveals that the rate-limiting step of glycolysis is variable, identifies new control mechanisms, and could help to predict the responses to targeting glycolysis to treat cancer.

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