44 results found
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Human Biology and Medicine

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off

    Sarah E Dremel, Neal A DeLuca
    Herpes simplex ICP4 preferentially binds to and delineates the viral genome, ultimately resulting in robust viral transcription at the expense of the host.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes

    Lauren N Booth et al.
    Nematode hermaphroditism has co-evolved with a self-sperm sensing mechanism that protects hermaphrodites from the detrimental effects of mating with males.
    1. Developmental Biology

    Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis

    Shauna L Houlihan et al.
    Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.
    1. Cell Biology
    2. Neuroscience

    Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth

    GaYoung Lee, Thomas L Schwarz
    Filamin, by recruiting a signaling complex to the postsynapse, orchestrates the correct formation and growth of postsynaptic membranes and localization of glutamate receptor subunits.
    1. Developmental Biology

    A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

    Nicholas S Kalson et al.
    Tendon fibroblast cells lay down a collagen matrix template during embryogenesis, and the expansion of this matrix drives post-natal tissue growth.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling et al.
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.
    1. Chromosomes and Gene Expression

    The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis

    Roland Ivanyi-Nagy et al.
    A messenger RNA coding for the histone 1.2 protein negatively regulates telomere elongation by interacting with human telomerase RNA.
    1. Developmental Biology
    2. Neuroscience

    Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body

    Najia A Elkahlah et al.
    Sensory innervation density in the insect associative learning center is set by postsynaptic cells and accomplished by flexible allocation of processes by presynaptic cells.

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