28 results found
    1. Evolutionary Biology

    Improved use of a public good selects for the evolution of undifferentiated multicellularity

    John H Koschwanez, Kevin R Foster, Andrew W Murray
    The ability to share resources for the benefit of all members of a group may have driven ancient organisms to evolve from a unicellular to a multicellular state.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

    Liana F Lareau, Dustin H Hite ... Patrick O Brown
    The size of the mRNA fragment protected by a ribosome depends on the ribosome's conformation, which enables studies of the distinct steps of decoding and translocation at single-codon resolution.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolving a 24-hr oscillator in budding yeast

    Gregg A Wildenberg, Andrew W Murray
    New complex traits can evolve through the elimination of genes in multiple unrelated pathways, rather than through the creation of new gene functions.
    1. Biochemistry and Chemical Biology
    2. Ecology

    De novo synthesis of a sunscreen compound in vertebrates

    Andrew R Osborn, Khaled H Almabruk ... Taifo Mahmud
    Many vertebrates are able to synthesize a sunscreen compound de novo and the pathway involved can be used for heterologous production of the compound in yeast.
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell, Jakob Vowinckel ... Markus Ralser
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    The evolution of adhesiveness as a social adaptation

    Thomas Garcia, Guilhem Doulcier, Silvia De Monte
    Mathematical modeling supports a scenario where cell-cell adhesion gradually evolves through natural selection, leading to the emergence of cohesive aggregates in microbial populations.
    1. Cell Biology
    2. Plant Biology

    Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

    Christoph A Bücherl, Iris K Jarsch ... Cyril Zipfel
    Although genetically and biochemically linked, the plant immune and growth receptors FLS2 and BRI1 form dispersed receptor clusters within the plasma membrane that are spatiotemporally separated.
    1. Chromosomes and Gene Expression

    Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

    Minghao Chia, Amy Tresenrider ... Folkert Jacobus van Werven
    Expression of a 5' extended mRNA isoform represses transcription of a downstream promoter.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

    Dorine Jeanne Mariëtte du Mee, Maxim Ivanov ... Sebastian Marquardt
    RNA Polymerase II transcriptional termination of a nuclear long non-coding RNA is required to maintain the mitochondrial genome and hence promotes budding yeast growth.
    1. Microbiology and Infectious Disease

    Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses

    Efraín E Rivera-Serrano, Olga González-López ... Stanley M Lemon
    Quasi-enveloped hepatitis A virions undergo clathrin-mediated endocytosis, followed by ALIX-dependent trafficking to lysosomes where the quasi-envelope is degraded, triggering uncoating of the RNA genome in association with lysosomal membrane rupture.

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