T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
Jaydeep Sidhaye, Philipp Trepte ... Jürgen A Knoblich
RNA-protein multiome approach helps to discover that the posttranscriptional regulation of the translational machinery is crucial for the fidelity of cortical development.
Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression.
A transcriptomic atlas of the mouse vomeronasal organ reveals novel receptor co-expression patterns and provides a framework for understanding sensory neuron lineage and receptor specification.
Junhao Li, Antonio Pinto-Duarte ... M Margarita Behrens
Loss of Dnmt3a in excitatory neurons disrupts synaptic morphology and behavior, and triggers the expansion of H3K27me3 binding, suggestive of increased polycomb repression.
Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
Alexander J Tarashansky, Jacob M Musser ... Bo Wang
Mapping single-cell atlases throughout Metazoa systematically characterizes cell type diversity and the evolution of their associated gene expression programs.
