1,879 results found
    1. Cell Biology
    2. Developmental Biology

    Par3 cooperates with Sanpodo for the assembly of Notch clusters following asymmetric division of Drosophila sensory organ precursor cells

    Elise Houssin et al.
    Baz/Par3 and Sanpdo are required for clustering and activation of Notch receptors to allow intra-lineage private communication following asymmetric division of Drosophila epithelial cells.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

    Benoit Roch et al.
    A viable separation of function XRCC4 knock-in mutant mouse model recapitulates some aspects of XRCC4 deficiency in humans, notably the absence of immune deficiency.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Genetics and Genomics

    The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila

    Brian Brown et al.
    The transcription factor Xrp1 mediates a previously unrecognized branch of stress-response signaling, specifically as a downstream effector of eIF2alpha kinases.
    1. Biochemistry and Chemical Biology

    HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

    Edgar E Boczek et al.
    Quantitative time-resolved crosslinking mass spectrometry is developed to monitor protein interactions and dynamics inside molecular condensates and used to identify misfolding of the RNA-binding domain of FUS as a key driver of condensate-aging.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Secondary metabolites of Hülle cells mediate protection of fungal reproductive and overwintering structures against fungivorous animals

    Li Liu et al.
    Xanthones produced by the filamentous fungus Aspergillus nidulans protect its sexual structures from predation by arthropods.
    1. Neuroscience

    A projectome of the bumblebee central complex

    Marcel Ethan Sayre et al.
    Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    microRNA-mediated regulation of microRNA machinery controls cell fate decisions

    Qiuying Liu et al.
    Genetic and biochemical analyses reveal that two stem-cell-specific microRNAs control stem cell fate decisions between pluripotency and differentiation through repressing Ago2, a key component of the microRNA machinery.
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber et al.
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.

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