A phase transition of TIR-1/SARM1 induced by either pathogen or non-pathogen stress potentiates its intrinsic NADase activity, which activates the p38 PMK-1 signaling cascade to induce protective immune defenses in Caenorhabditis elegans intestinal epithelial cells.

UV-Vis- and IR-spectroscopy provides insights into the light-induced enzyme activity of a rhodopsin guanylyl cyclase by tracking the substrate turnover with atomic resolution in real-time and correlating it with the structural changes of the protein.

Similar evolutionary pressures on gene expression between human and chimpanzee populations contribute to the observation that inter-individual gene expression variability is similar across genes in these species.

TIR-1 regulates both repair and destruction on either side of an injury axon.

Increased usability and validity of neuroscience models, through FAIR workflows for the whole modeling process, including data and model management, parameter estimation, uncertainty quantification, and model analysis.

The NWB data language enables reproduction, interchange, and reuse of diverse neurophysiology data, and the design principles of NWB are generally applicable to enhance discovery across biology through data FAIRness.

A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.

The most prolific and oldest locality in which a rich dinosaur bonebed and fossiliferous amber have been found in association is revealed, allowing the reconstruction of an ancient terrestrial ecosystem with a detail and accuracy reached only exceptionally in palaeontology.