437 results found
    1. Structural Biology and Molecular Biophysics

    Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

    Claire Dickson et al.
    Phosphorylation deactivates TRIM21 B Box autoinhibition to licence proinflammatory signalling by cytosolic antibodies.
    1. Cell Biology
    2. Neuroscience

    FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

    Tae-In Kam et al.
    By binding to Fc gamma receptor IIb, amyloid beta induces a series of phosphorylation events that mediate the damaging effects of hyperphosphorylated tau proteins in Alzheimer's disease.
    1. Cancer Biology
    2. Cell Biology

    Chimeric antigen receptors that trigger phagocytosis

    Meghan A Morrissey et al.
    A family of engineered immune receptors trigger internalization of cancer cells and antigen-coated targets.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A potent human neutralizing antibody Fc-dependently reduces established HBV infections

    Dan Li et al.
    A novel and potent receptor-binding-blockage human neutralizing antibody prevents HBV infection, and suppresses HBV infection therapeutically in HBV-infected mice.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

    Ayesa Syenina et al.
    Building on previous work (St John et al., 2013), we explain why secondary infection by dengue virus is associated with more severe vascular disease than primary infection.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status

    Dongming Li et al.
    The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.
    1. Immunology and Inflammation

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al.
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    1. Developmental Biology

    Loss of Ptpn11 (Shp2) drives satellite cells into quiescence

    Joscha Griger et al.
    The stem cells of the postnatal muscle allow postnatal muscle growth and repair and withdraw from the cell cycle when the tyrosine phosphatase Ptpn11 (Shp2) is inhibited or mutated in mice.
    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.

Refine your results by:

Type
Research categories