442 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Electron tomography visualization of HIV-1 fusion with target cells using fusion inhibitors to trap the pre-hairpin intermediate

    Mark S Ladinsky et al.
    Visualization of HIV-1 fusion by trapping the prehairpin intermediate.
    1. Immunology and Inflammation
    2. Neuroscience

    Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

    Jeremy Carlos Burns et al.
    Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.
    1. Developmental Biology
    2. Immunology and Inflammation

    Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

    Racquel Domingo-Gonzalez et al.
    Single cell transcriptomics reveal a complex orchestration of lung immune cells during the transition from fetal to air-breathing life to fill context-specific functions in tissue remodeling, angiogenesis, and immunity.
    1. Immunology and Inflammation

    Umbilical cord blood-derived ILC1-like cells constitute a novel precursor for mature KIR+NKG2A- NK cells

    Sabrina Bianca Bennstein et al.
    Neonatal ILC1-like cells are functionally immature but have the unique potential to generate NK cells characterized by downregulation of NKG2A and a highly diverse KIR receptor repertoire.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Human Biology and Medicine
    2. Neuroscience

    Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm

    Heidi IL Jacobs et al.
    By combining ultra-high-field imaging with physiological and saliva measures it is established that interactions between locus coeruleus, hippocampus and amygdala vary along emotional memory stages, putatively reflecting distinct cognitive states.
    1. Biochemistry and Chemical Biology

    Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

    Ryan R Cupo, James Shorter
    Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.
    1. Immunology and Inflammation

    Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

    Eui Ho Kim et al.
    Experiments in mice provide insights into the immunological mechanisms of action the vaccine adjuvant MF59.
    1. Microbiology and Infectious Disease

    Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

    PJ Klasse, John P Moore
    Antibodies hold promise for breakthrough treatment of COVID-19, the disease caused by the coronavirus SARS-CoV-2.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma et al.
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.

Refine your results by:

Type
Research categories