546 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

    Philipp Kolb et al.
    Molecular mechanisms reveal that human cytomegalovirus has evolved to deploy two individual glycoproteins working in synergy to efficiently evade antibody-mediated immunity mediated by Fc-gamma receptors.
    1. Structural Biology and Molecular Biophysics

    Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

    Claire Dickson et al.
    Phosphorylation deactivates TRIM21 B Box autoinhibition to licence proinflammatory signalling by cytosolic antibodies.
    1. Cell Biology
    2. Neuroscience

    FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

    Tae-In Kam et al.
    By binding to Fc gamma receptor IIb, amyloid beta induces a series of phosphorylation events that mediate the damaging effects of hyperphosphorylated tau proteins in Alzheimer's disease.
    1. Cancer Biology
    2. Cell Biology

    Chimeric antigen receptors that trigger phagocytosis

    Meghan A Morrissey et al.
    A family of engineered immune receptors trigger internalization of cancer cells and antigen-coated targets.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro et al.
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity

    Gunjan Arora et al.
    Red blood cells infected by the malaria parasite Plasmodium falciparum are destroyed by human natural killer cells in the presence of antibodies from people who have acquired clinical immunity to malaria.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A potent human neutralizing antibody Fc-dependently reduces established HBV infections

    Dan Li et al.
    A novel and potent receptor-binding-blockage human neutralizing antibody prevents HBV infection, and suppresses HBV infection therapeutically in HBV-infected mice.
    1. Neuroscience

    Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

    Leanne M Holt et al.
    Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

    Diana Gumber et al.
    Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    EphA7 promotes myogenic differentiation via cell-cell contact

    Laura L Arnold et al.
    The juxtacrine signaling molecule EphA7, when expressed on terminally-differentiated myocytes, non-cell-autonomously induces adjacent myoblasts to also commit to terminal differentiation leading to rapid coordinated differentiation across the entire population.

Refine your results by:

Type
Research categories