256 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

    Kira Cozzolino, Lynn Sanford ... Dylan J Taatjes
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques

    Nico A Flierman, Sue Ann Koay ... Chris I De Zeeuw
    Dentate nucleus neurons can dynamically modulate their activity during a visual attention task, comprising not only sensorimotor but also cognitive attentional components.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology

    An increase in reactive oxygen species underlies neonatal cerebellum repair

    Anna Pakula, Salsabiel El Nagar ... Alexandra L Joyner
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Neuroscience

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Medicine

    NK cell exhaustion in Wilson’s disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis

    Yong Jin, Jiayu Xing ... Qingsheng Yu
    Metabolic abnormalities in hepatocytes cause the alteration of transcriptional profile and function of immune cells in the tissue microenvironment.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

    Simei Go, Constantinos Demetriou ... Eric O Neill
    Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.
    1. Cancer Biology
    2. Evolutionary Biology

    High-density sampling reveals volume growth in human tumours

    Arman Angaji, Michel Owusu ... Johannes Berg
    Spatial genomics reveals the mode of evolution of a tumour based on the positions of mutations in high-resolution samples.
    1. Immunology and Inflammation

    T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type 1 cells

    Josep Garnica, Patricia Sole ... Pere Santamaria
    T-regulatory type 1 cells inherit a broad repertoire of epigenetic marks from T-follicular helper T-cells, offering new insights into the developmental biology of this subset.
    1. Microbiology and Infectious Disease

    Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

    Shuai Ma, Bin Yang ... Lingyan Jiang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete

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