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Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.

In a study of a herpes simplex virus (HSV) vaccine, the combination of sex and prior exposure to the virus resulted in HSV naive women mounting a prominent type I interferon response associated with reduced neutralizing titers to HSV.

Maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.

Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.

Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.

Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.

The induction of ISG15 during bacterial infection can be independent of Type I Interferons and leads to an increase in the secretion of cytokines known to be critical for bacterial clearance.

Two novel subsets of microglia identified by their unique autofluorescence profiles differ in their subcellular organization, proteomic signatures and in their response to aging and lysosomal dysfunction.