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Human Biology and Medicine
Down regulation of vestibular balance stabilizing mechanisms to enable transition between motor states
Romain Tisserand et al.
Down regulation of the gain from the vestibular sensory sources prior to the initiation of movement is a motor control solution to overcome the reflex-stabilizing mechanisms to enable motion from a postural orientation.
Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat
Hala Harony-Nicolas et al.
The production, validation and study of a novel rat model for Phelan McDermid Syndrome shows an ameliorative effect of oxytocin on both social and attentional deficits.
Chromosomes and Gene Expression
The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity
Yeha Kim et al.
Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
Human Biology and Medicine
Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression
Nuno Rocha et al.
Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
Dyslexics’ faster decay of implicit memory for sounds and words is manifested in their shorter neural adaptation
Sagi Jaffe-Dax et al.
Implicit memory traces for recently encountered perceptual stimuli, including words, decay more quickly in people with dyslexia.
Microbiology and Infectious Disease
Motility precedes egress of malaria parasites from oocysts
Dennis Klug, Friedrich Frischknecht
A surface protein triggers intra-oocyst motility of Plasmodium sporozoites to ensure parasite egress from oocysts.
Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons
Jiangnan Luo et al.
Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.
degradation in the germ plasm safeguards germline development
Catherine E Eichler et al.
RNP granules confer temporal and spatial regulation of
mRNA degradation to minimize inheritance of
mRNAby germ cells and thereby protect germline development.
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts
Tushar D Bhagat et al.
Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium
Karen Baker et al.
IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
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