Genetic association analyses in Latin American individuals revealed two additional loci associated with COVID-19 that were not previously found in other population groups.
The lysine acetyltransferases KAT2A and KAT2B regulate the dynamic chromatin association of the tumour suppressor protein PALB2, protecting active genes and promoting DNA damage repair in a context-dependent manner.
Joshua L Lillvis, Hideo Otsuna ... Barry J Dickson
A new approach for fast, sparse neural circuit mapping allows circuit structure, physiology, and behavior to be quantified in the same animal and across many animals.
Catherine Baranowski, Michael A Welsh ... E Hesper Rego
Polar elongating mycobacteria (Mycobacterium smegmatis) require specific cell wall chemistries, those catalyzed by targets of critical antibiotics, to maintain rod shape at aging sites of the bacillus.
Justinn Barr, Maria Elena Gentile ... Andrew E Vaughan
Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.
The absence of helminth parasites in developed countries may be exacerbating pathological, age-associated inflammation, known as inflammaging, suggesting that helminth therapies could provide protection against age-related disease.
Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.