Transcriptional modules underlie the step-wise construction of neural circuits in the Drosophila visual system.

Multiomic analyses provide new insights into the involvement of transposable elements in T-cell development in the thymus and central tolerance induction.

In neocortex, Nav1.1 is expressed in neocortical pyramidal tract projection neurons and a minor subpopulation of cortico-cortical projection neurons in addition to its predominant expression in inhibitory neurons, while the majority of cortico-thalamic, cortico-striatal, and cortico-cortical neurons express Nav1.2.

Automated whole-brain analysis of gene expression at cellular resolution detects previously overlooked phenotypes in mutants and reveals parallels between the forebrains of zebrafish and mammals.

Kv1.1 potassium channels regulate postnatal neurogenesis in the hippocampus via increasing the membrane excitability that activates the TrkB signaling pathway in a cell-autonomous manner.

Lmo4 specifies two neuron subclasses in the mouse neocortex by promoting postnatal co-expression of the transcription factors Ctip2 and Satb2 via chromatin remodelling in a time and area-specific manner.

Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.

Combination of experimental mouse models with single-cell RNA-sequencing creates a detailed map of medullary thymic epithelial cell development and identifies a transit-amplifying population as the immediate precursor to Aire-expressing mTECs.

Self-reactive CD4⁺ thymocytes have a broad impact on the composition of medullary thymic epithelial cell (mTEC) subsets by acting upstream of Aire⁺ mTECs, which conditions the induction of T-cell tolerance.