Fibroblast growth factor (FGF) ligands exhibit different preferences for signaling cascades triggered through FGFR1, a receptor which is critical for skeletal development, and these differences likely contribute to the amazing complexity of developmental processes.
Sruthi Purushothaman, Ahmed Elewa, Ashley W Seifert
While movement of Fgf-signaling to the limb mesenchyme accompanied a shift in function, the ultimate outcome remains a convergent tetrapod limb phenotype.
A novel 2D-to-3D human brain organoid protocol reveals the pivotal role of FGF8 signaling in driving regional patterning and cellular diversity, while also modulating genes crucial for both normal and pathological neural development.
Elizabeth D Kirby, Sandra E Muroy ... Daniela Kaufer
Exposing rats to acute stress increased the generation of new neurons in a subregion of the hippocampus, and improved the animals' performance in a memory task two weeks later.