A hitherto unknown role of Piezo1 mechanosensors in chemotactic migration of human T cells is identified, linking focal adhesion formation to integrin recruitment.

The analysis of T cell movement in multiple tissues (lymph node, villi, and lung under two different inflammatory conditions) sheds new light on how T cells navigate different tissue environments to improve immunity and search processes.

Androgen receptor activation modifies B cell frequencies and functionality, accompanied by weight gain in female mice exposed to human PCOS IgG, highlighting the unrecognized involvement of B cells in PCOS autoimmune comorbidities despite their absence not preventing PCOS phenotype development.

Hypertrophic chondrocytes of the growth plate undergo a process of dedifferentiation to generate marrow associated skeletal stem and progenitor cells (SSPCs), which ultimately re-differentiate into cells of the osteoblast or adipocyte lineages during skeletal development.

A novel secondary adipogenesis pathway is defined that is unique to the bone marrow and is activated with age and in states of metabolic stress.

Upon Toxoplasma gondii infection, IL-33 plays a critical role in driving early anti-parasite responses by innate lymphoid cells rendered responsive to its effects by infection.

Antigen-phosphorothioate DNA conjugation provides a vaccination strategy where stable barcodes facilitate the detection and quantification of antigen using single-cell RNA sequencing.

Murine periosteum is highly enriched for osteoprogenitors, many of which express αSMA, but fracture callus chondrocytes are partially derived from other sources.

eMags is an engineered photodimerizer pair for optogenetic modulation in mammalian cells that is especially suited for the manipulation of intracellular processes occurring in small volumes or subcellular organelles.