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    1. Ecology

    The lost world of Cuatro Ciénegas Basin, a relictual bacterial niche in a desert oasis

    Valeria Souza et al.
    At Cuatro Ciénegas, the ancestral niche conditions of the ancient shores of Laurentia persisted along with its microbial communities that have been coevolving for a very long time.
    1. Plant Biology

    Antimicrobial peptide expression in a wild tobacco plant reveals the limits of host-microbe-manipulations in the field

    Arne Weinhold et al.
    The attempt to manipulate a microbiome in planta to study the ecological consequences under field conditions leaves plants and their microbes surprisingly unimpressed.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin et al.
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Large protein organelles form a new iron sequestration system with high storage capacity

    Tobias W Giessen et al.
    An alternative iron storage system based on a 9.6 megadalton microbial protein compartment is able to sequester and store large amounts of iron.
    1. Cell Biology
    2. Immunology and Inflammation

    Rapamycin rejuvenates oral health in aging mice

    Jonathan Y An et al.
    Short-term treatment with rapamycin reverses periodontal bone loss, attenuates inflammation, and remodels the oral microbiome toward a more youthful state.
    1. Microbiology and Infectious Disease

    Gut microbiota density influences host physiology and is shaped by host and microbial factors

    Eduardo J Contijoch et al.
    The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Reformulation of an extant ATPase active site to mimic ancestral GTPase activity reveals a nucleotide base requirement for function

    Taylor B Updegrove et al.
    Reengineering the nucleotide-binding pocket of an extant ATPase to restore ancestral GTPase activity revealed an ATP-dependent intermediate required for function and suggested why the protein evolved to use ATP.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA

    Zachary F Mandell et al.
    The general transcription elongation factor NusG functions as an intrinsic termination factor in Bacillus subtilis and together with NusA coordinates global gene expression including the motility regulon.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren et al.
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A selective gut bacterial bile salt hydrolase alters host metabolism

    Lina Yao et al.
    The deletion of a single gene encoding a selective bile salt hydrolase from the abundant human gut bacterium Bacteroides thetaiotaomicron significantly alters host metabolism.