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Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.

Blockage of CXCL10/CXCR3 signaling between murine pancreatic precancerous lesion cells and inflammatory macrophages generates a tumor-promoting microenvironment.

The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.

The hepcidin regulator erythroferrone functions by sequestering BMPs and is an important modulator of bone remodeling, providing new mechanistic insight into how premature osteoporosis persists in optimally transfused β-thalassemic patients.

Visual attention modulates the integration of the evidence that is most useful for achieving a goal in both perceptual and value-based decisions.

Grid-cell maps can be aligned to both local and remote reference frames, suggesting that they provide a metric for space beyond the navigationally accessible boundaries of the local environment.

Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.

A model framework and toolbox to quantify metacognitive biases and sources of metacognitive noise in animal and human confidence data.

By linking export and licensing of a piRNA precursor transcript, channel nuclear pore complex subunits Nup54 and Nup58 are specifically required to silence transposons in the Drosophila ovary.

SpoIIIE forms a protein channel that spans the two lipid bilayers of the septum and mediates chromosome translocation and reversible membrane fission during Bacilus subtilis sporulation.