10,510 results found
    1. Physics of Living Systems

    Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

    Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
    Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
    1. Biochemistry and Chemical Biology

    Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

    Marta Carroni, Kamila B Franke ... Axel Mogk
    Head-to-head interactions of regulatory coiled-coil domains control activity of the central bacterial AAA+ protein ClpC by promoting formation of a reversible resting state.
    1. Developmental Biology
    2. Physics of Living Systems

    Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

    Guizela Huelsz-Prince, Rutger Nico Ulbe Kok ... Jeroen S van Zon
    Tracking of all cells in intestinal organoids crypts to fully reconstruct cell lineages reveals that proliferative behavior is highly symmetric between sisters cells, while simulations show that this observed symmetry minimizes random fluctuations in cell proliferation, thereby ensuring homeostasis.
    1. Neuroscience

    Persistent firing in LEC III neurons is differentially modulated by learning and aging

    Carmen Lin, Venus N Sherathiya ... John F Disterhoft
    Temporal associative learning enhances persistent firing in lateral entorhinal cortex (LEC) layer III neurons, while aging decreases persistent firing, leading to cognitive impairments.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

    Molly Brothers, Jasper Rine
    Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.
    1. Ecology

    Group size and composition influence collective movement in a highly social terrestrial bird

    Danai Papageorgiou, Damien Roger Farine
    High-resolution GPS data revealed a quadratic relationship between group size and movement, with vulturine guineafowl groups of intermediate size exhibiting the largest home-range size and greater variation in site use.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift, Krithika Rajaram ... Sean T Prigge
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.
    1. Neuroscience

    Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

    Katrin Franke, Chenchen Cai ... Andreas Savas Tolias
    Widespread color-opponency in mouse V1 enhances object decoding in the sky, highlighting the evolutionary importance of color processing in non-primate species.
    1. Ecology

    Habitat and social factors shape individual decisions and emergent group structure during baboon collective movement

    Ariana Strandburg-Peshkin, Damien R Farine ... Iain D Couzin
    For baboons on the move, habitat features across multiple spatial scales combine with social interactions to impact the movements of individuals, ultimately shaping the structure of the whole group.
    1. Neuroscience

    Hippocampal theta coordinates memory processing during visual exploration

    James E Kragel, Stephen VanHaerents ... Donna J Bridge
    Eye movements time-locked to retrieval and novelty during learning preferentially occur at distinct phases of hippocampal theta.

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