224 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

    Tsutomu Aoki, Ali Sarkeshik ... Paul Schedl
    A chromatin boundary factor that is only active during early embryo development has been discovered in Drosophila.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    A global change in RNA polymerase II pausing during the Drosophila midblastula transition

    Kai Chen, Jeff Johnston ... Julia Zeitlinger
    The first zygotic genes are transcribed without RNA polymerase II pausing from a TATA-enriched promoter.
    1. Stem Cells and Regenerative Medicine

    Transgressions of compartment boundaries and cell reprogramming during regeneration in Drosophila

    Salvador C Herrera, Ginés Morata
    The reconstruction of damaged structures during regeneration requires cell reprogramming mediated by the up regulation of the JNK pathway and the transient debilitation of the epigenetic control mechanism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Bacterial actin MreB forms antiparallel double filaments

    Fusinita van den Ent, Thierry Izoré ... Jan Löwe
    The prokaryotic actin homologue MreB forms antiparallel double filaments in vitro and in vivo, an architecture that is unprecedented among the actin family of proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Large-scale filament formation inhibits the activity of CTP synthetase

    Rachael M Barry, Anne-Florence Bitbol ... Zemer Gitai
    The accumulation of its product, cytidine triphosphate, encourages the enzyme CTP synthetase (CtpS) to form large-scale polymers and inhibits the enzyme's activity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Histone supply regulates S phase timing and cell cycle progression

    Ufuk Günesdogan, Herbert Jäckle, Alf Herzig
    Controlling cell cycle progression in a developing embryo directly depends on de novo histone supply and a specialized surveillance mechanism for nucleosome assembly.
    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Bacterial Proliferation: Off the wall

    Dennis Claessen, Gilles P van Wezel
    Version of Record
    Insight
    1. Cell Biology
    2. Microbiology and Infectious Disease

    General principles for the formation and proliferation of a wall-free (L-form) state in bacteria

    Romain Mercier, Yoshikazu Kawai, Jeff Errington
    A wide range of bacterial species can switch into a cell wall-free state that does not require the FtsZ-based division machinery to proliferate.
    1. Cell Biology

    A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells

    Marcella L Erb, James A Kraemer ... Joe Pogliano
    A bacteriophage tubulin homolog, PhuZ, forms a structure with the biochemical, structural, and functional properties of a simplified, bipolar spindle.

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