3,628 results found
    1. Neuroscience

    Sensory Neurons: A new target for G protein signaling

    László Csanády
    G protein-coupled receptor stimulation inhibits TRPM3 channel activity through direct binding of the Gβγ subunit to the channel.
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    1. Neuroscience

    Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

    Doreen Badheka et al.
    Electrophysiological experiments, Ca2+ imaging, and behavioral studies in mice identify the TRPM3 ion channel as a novel target of G-protein βγ subunits.
    1. Cell Biology
    2. Plant Biology

    Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor

    Xiangxiu Liang et al.
    Heterotrimeric G proteins are coupled to and regulate plant receptor signaling, which allows optimum immune activation and enhances the production of reactive oxygen species.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

    Nicolas Aznar et al.
    Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

    Ravi Kant et al.
    Hydrogen-Deuterium exchange experiments show that Ric-8A induces similar dynamic changes in the structure of Gα as G protein-coupled receptors, yet protects a larger surface of the nucleotide-binding Ras domain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins

    Katja Gotthardt et al.
    The ciliary G-protein Arl13B – which is often mutated in Joubert syndrome – is the Guanine nucleotide exchange factor for the G-protein Arl3 and exclusively localizes to cilia.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

    Weiwei Wang et al.
    The G protein subunits Gβγ and the signaling lipid PIP2 are simultaneously needed to activate the potassium ion channel GIRK2 to control the voltage across a lipid bilayer, while sodium ions modulate these molecules' effects.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

    Javier García-Nafría et al.
    The adenosine A2a receptor couples to the heterotrimeric G protein Gs using both conserved contacts seen in other complexes and, in addition, novel contacts to the beta subunit of the G protein.
    1. Cell Biology
    2. Neuroscience

    Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling

    Keqiang Xie et al.
    A G protein in striatal neurons forms preassembled complexes with its downstream enzyme, adenylyl cyclase, which has implications for the pathophysiology of movement disorders.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor

    Anthony W Azevedo et al.
    Serine and threonine phosphorylation sites work in concert to provide rapid and reproducible desensitization of the G-protein coupled receptor rhodopsin.

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