The condensin I subunit Cap-G is expressed in post-mitotic neurons and its removal, especially from less mature neurons, results in gene expression changes, reduced survival and behavioural defects in Drosophila.

An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.

A G protein in striatal neurons forms preassembled complexes with its downstream enzyme, adenylyl cyclase, which has implications for the pathophysiology of movement disorders.

In nematode worms, the length of the male refractory period–the time between matings–is regulated by multiple transmitters including dopamine, which both promotes ejaculation and reduces the activity of males post-copulation.

Differences in the kinetics of G protein activation can explain why only some receptors can activate potassium ion channels called GIRKs.

Despite employing diverse molecular mechanisms, many different cell signaling systems avoid losing information by transmitting it in a linear manner.

Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.