226 results found
    1. Neuroscience

    Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

    Zhe Zhang et al.
    Postnatal, postsynaptic loss of FMRP specifically weakens callosal synaptic inputs onto L2/3 pyramidal neurons, in requirement ofnormal sensory experience, through downregulating AMPA receptor transmission and without affecting local synaptic inputs during cortical circuit development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

    Vinay V Eapen et al.
    A combination of spatial proteomic and autophagic flux approaches was used to reveal the landscape of turnover of damaged lysosomes, demonstrating a key role for the autophagy receptor TAX1BP1 and its associated kinase TBK1 in both HeLa cells and iNeurons.
    1. Neuroscience

    Modeling spinal locomotor circuits for movements in developing zebrafish

    Yann Roussel et al.
    Computational models of spinal locomotor circuits in developing zebrafish reveal how new movements can emerge during development through the integration of new spinal neurons and new connections.
    1. Cell Biology
    2. Plant Biology

    Members of the ELMOD protein family specify formation of distinct aperture domains on the Arabidopsis pollen surface

    Yuan Zhou et al.
    Pollen aperture patterning in Arabidopsis is controlled by members of the ELMOD protein family, whose expression levels in developing pollen lineage are tightly regulated.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar et al.
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Cell Biology

    Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

    Yoanna Ariosa-Morejon et al.
    Protein dynamics signatures in ageing collagen-rich tissues that are central to frequent age-related diseases such as osteoporosis and osteoarthritis.
    1. Genetics and Genomics
    2. Neuroscience

    Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

    Sonia Coni et al.
    A decrease of the type 2 myotonic dystrophy gene product CNBP causes an impairment of polyamine metabolism and locomotor dysfunction that can be reverted with polyamine supplementation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    β-hydroxybutyrate accumulates in the rat heart during low-flow ischaemia with implications for functional recovery

    Ross T Lindsay et al.
    β-Hydroxybutyrate accumulates in the perfused rat heart during ischaemia, driven by flux through both HMGCS and SCOT, with implications for functional recovery.
    1. Immunology and Inflammation

    ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation

    Miaomiao Tian et al.
    Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.
    1. Neuroscience

    Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose

    Cheng Qian et al.
    Identification of novel vesicular transporters will shed light on to expanding the chemical diversity of neurotransmitters or neuromodulators.

Refine your results by:

Type
Research categories