106 results found
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modelling primaquine-induced haemolysis in G6PD deficiency

    James Watson et al.
    In silico modelling of all available data shows that a twenty-day ascending-dose primaquine regimen could be safe to administer to G6PD deficient patients for the radical cure of vivax malaria.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia

    Geraldine M Clarke et al.
    Increasing levels of glucose-6-phosphate dehydrogenase deficiency are associated with decreasing risk of cerebral malaria, but with increased risk of severe malarial anaemia.
    1. Epidemiology and Global Health

    Protective effect of Mediterranean-type glucose-6-phosphate dehydrogenase deficiency against Plasmodium vivax malaria

    Ghulam R Awab et al.
    The Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency confers a strong gene-dose proportional protective effect against symptomatic Plasmodium vivax malaria in the Pashtun ethnic group.
    1. Epidemiology and Global Health

    Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria

    James A Watson et al.
    Selection bias, also known as collider bias, likely explains the apparent protective effect of G6PD deficiency against cerebral falciparum malaria.
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    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production

    Blake R Wilde et al.
    The MondoA transcription factor localizes to the outer mitochondrial membrane where it coordinates an adaptive transcriptional response to elevated cellular energy represented by high cytoplasmic glucose and high mitochondrial ATP.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan et al.
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Cell Biology

    Cross-compartment signal propagation in the mitotic exit network

    Xiaoxue Zhou et al.
    The mitotic exit network signals from spindle pole bodies to the nucleolus through the dynamic localization of its terminal kinase complex Dbf2-Mob1.
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer et al.
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Sex-based differences in clearance of chronic Plasmodium falciparum infection

    Jessica Briggs et al.
    Lower malaria prevalence in females does not appear to be due to lower rates of infection but rather due to faster clearance of asymptomatic infections.
    1. Cell Biology

    Assigning mitochondrial localization of dual localized proteins using a yeast Bi-Genomic Mitochondrial-Split-GFP

    Gaétan Bader et al.
    The Bi-Genomic Mitochondrial-Split-GFP, where both fragments of the Split-GFP are expressed by separated translation machineries, shuts off cytosolic fluorescence of dual-localized proteins, allowing visualization of their mitochondrial echoforms.

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